[Effects of some drugs on the bile flow].

Five functions relating to the bile excretion were recorded simultaneously; that is, pressures of the gall bladder and the common bile duct, amount of bile discharged into the duodenum, spike discharges of the sphincter of Oddi and the duodenal wall. In the observation of motility of the sphincter of Oddi, we used the rubber tube passing through it. Bile flow into the duodenum was continuously measured by the change in pressure. The effects of some drugs were; Ursodesoxycholate, 10 mg/Kg; evidently increased the volume of bile, and induced the relaxation of the bile excretion. Pancreozymin, 5 units/Kg; stimulated the five functions. BaC12, 4 mg/Kg; showed the similar effect as Pancreozymin, but the bile excretion was discontinued. Morphine, 5 mg/Kg; enlarged the spike discharge. Adrenaline, 5 ,ug/Kg; exerted inhibitory effect on the five functions. We would assume from these results as follows; the gall bladder acts to accumulate the bile and controls the pressure of the common bile duct. Bile flow is controlled not only by the common bile duct, but the sphincter of Oddi participates to control of the bile flow. The sphincter of Oddi has the most important role in the bile flow and the bile flow is mainly allowed by the relaxation of the sphincter of Oddi.